0324: Cardioprotection against ischemia-reperfusion injury by heart rate control
نویسندگان
چکیده
منابع مشابه
Spotlight on cardioprotection against ischemia-reperfusion injury.
Worldwide, coronary heart disease (CHD) causes approximately one-third of all deaths in men and one-quarter of all deaths in women and represents a significant threat to public health. The global burden of CHD in terms of disability-adjusted life years (DALY) or " healthy years of life lost " is projected to increase from around 47 million DALY globally in 1990 to 82 million in 2020 [1]. Myocar...
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Cardiovascular diseases are still the main cause of mortality around the world. Therefore, it is essential to develop practical means to reduce their burden. A wealth of evidence supports the role of physical exercise in attenuating many of the risk factors of cardiovascular diseases. Moreover, endurance training warrants protection against myocardial infarction. Exercise, even if performed ...
متن کاملPast and present course of cardioprotection against ischemia-reperfusion injury.
Despite tremendous advances in cardiovascular research and clinical therapy, ischemic heart disease remains the leading cause of serious morbidity and mortality in western society and is growing in developing countries. For the past 5 decades, many scientists have studied the pathophysiology of myocardial ischemia-reperfusion (I/R) injury leading to infarction. With the exception of reperfusion...
متن کاملNaringenin confers cardioprotection against ischemia-reperfusion injury in aged rats
Recent data of ours demonstrate that naringenin, a flavanone derivative typical of the Citrus genus, possesses cardioprotective effects in rat hearts submitted to ischemia/reperfusion injury [Testai et al., 2013a]. These effects are due, at least in part, to a mitochondria-targeted action, since naringenin activates a mitochondrial calcium-dependent potassium channel (mitoBKCa), localized in th...
متن کاملLiver ischemia preconditions the heart against ischemia-reperfusion arrhythmias
Objective(s):This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. Materials and Methods: Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induce...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2014
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(14)71347-3